Tuesday October 12 , 2010, from 12.00 to 13.00
Seminar with Laure Ysebrant de Lendonck
"Contribution of IFR3 in T cell differentiation"
Polarization of CD4 or CD8 T cell into IL-17 effector cells is tightly controlled as these cells have been implicated in autoimmune inflammation. Herein, we identified a novel regulatory pathway that restrains IL-17 production in CD8 T cells. We observed that polyclonally-stimulated naïve CD8 T cells from IRF3-/- mice produce large amounts of IL-17A in vitro and in vivo upon adoptive transfer in syngeneic RAG-/- mice. These cells are highly pathogenic as reconstituted mice rapidly develop cutaneous lesions and wasting disease. This project attempts to decipher the cellular and molecular mechanisms implicated in this finding both in vitro and in vivo.