Tuesday April 27, 2010, from 12.00 to 13.00
"Antigen recognition by gammadelta T cells"
For most gammadelta T cell subsets it is not known what their T cell receptor (TCR) recognizes, i.e. what the antigen or ligand is. After a general introduction on gammadelta T cells, David Vermijlen will focus on the well described interaction of a mouse gammadelta TCR with its ligand, the non-classical MHC class I molecule T22/T10. This interaction clearly differs from the recognition of classical MHC class I by alphabeta T cells. In this context, David Vermijlen will present as well recent data obtained at the Institute for Medical Immunology regarding the fetal gammadelta T cell response against CMV infection in utero. This includes the identification of a public germline-encoded anti-CMV gammadelta TCR.