|December 15 - Common seminar IBMM-IMI with Jean-Christophe Marine, University of Ghent, VIB laboratory for molecular cancer biology, Ghent|
(this seminar will be followed by a lunch from 13.00 to 14.00)
"MicroRNA-processing and tumorigenesis"
MicroRNAs (miRs) are non-coding RNAs that regulate gene expression by targeting messenger RNAs for translational repression and/or degradation. It has become apparent that miRs and molecules involved in their biogenesis contribute to tumorigenesis. Overall down-regulation of miR levels in cancer has been reported and this down-regulation, likely to be at least partly a consequence of aberrant processing of their precursor transcripts, appears to contribute significantly to the progression of the disease. To further study the role of the miR-processing machinery in cancer development, Dicer function has been genetically ablated in a mouse model of retinoblastoma (Chx10-cre;Rblox/lox; p107-/-). Our data suggest that Dicer functions as a haplo-insufficient tumor suppressor gene in retinoblastoma at least partly by compromising p53 tumor suppressor function.
|- February 15 : Biopark seminar with Susan Gasser> Read More|
|- February 28 : Bioké formation on flow cytometry> Read More|
|Recent publication in Am J Transplant> Read More|
|CMMI Center for Microscopy and Molecular Imaging|
BioWin Pôle de Compétitivité Santé de Wallon e
IBMM Institut de Biologie et de Médecine Moléculaires
GIGA Groupe Interdisciplinaire de Génoprotéomique Appliquée
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