|June 10, 2008 - Seminar with Olivier Thaunat, Hôpital Edouard Herriot, Lyon|
|Lymphoid neogenesis during chronic rejection: evidence for a local alloimune response|
|Tuesday 10 june, 12.00 to 13.00 PM|
Département de Transplantation et d'Immunologie Clinique, Hôpital Edouard Herriot, Lyon
"Lymphoid neogenesis during chronic rejection: evidence for a local alloimune response"
Although chronic rejection is currently the main cause of long-term allograft failure, its pathogenesis remains elusive, hereby preventing the development of effective therapy.
Recent advances in the comprehension of the pathophysiology of chronic inflammatory diseases could shed new light on the pathogenesis of chronic rejection. Lymphoid neogenesis is a mechanism responsible for the progressive organization of chronic inflammatory infiltrates into functional ectopic germinal centers, which has been recently evidenced in various pathological situations sharing a common feature: the failure of the immune response to eradicate the targeted antigen(s). Chronic rejection is such a situation as it results from a sustained alloimmune response against donor's antigens that are constantly replenished by the grafted tissue. Accordingly, functional ectopic germinal centers develop within chronically rejected organs. This implies that during chronic rejection graft is at the same time the target and the site of elicitation of the alloimmune response.
|- February 15 : Biopark seminar with Susan Gasser> Read More|
|- February 28 : Bioké formation on flow cytometry> Read More|
|Recent publication in Am J Transplant> Read More|
|CMMI Center for Microscopy and Molecular Imaging|
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IBMM Institut de Biologie et de Médecine Moléculaires
GIGA Groupe Interdisciplinaire de Génoprotéomique Appliquée
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