Stéphane Temmerman, PhD, joined the Institute for Medical Immunology in January 2008.  He will conduct as principal investigator a research project aiming at the development of new strategies to generate tolerogenic immune cells and the identification of novel cell signaling intermediates.  Stéphane Temmerman begins his research career at the ULB under the mentorship of Françoise Mascart, MD, PhD.  In 2004, he received a PhD degree for his work on a candidate antigen for a new vaccine against tuberculosis.  His discovery on the critical role of antigen methylation for immune recognition was published in Nature Medicine.  He was then appointed as post-doctoral fellow in the group of Ashish Jain at the National Institutes of Health (Bethesda, USA) where he gained expertise in molecular signaling and identified a new genetic defect responsible for primary immune deficiency in humans.

Key bibliographic references of Stéphane Temmerman 

Temmerman S, Pethe K, Parra M, Alonso S, Rouanet C, Pickett T, Drowart A, Debrie AS, Delogu G, Menozzi FD, Sergheraert C, Brennan MJ, Mascart F, Locht C. Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nat Med 2004 ; 10 : 935-941.

Temmerman ST, Ma CA, Borges L, Kubin M, Liu S, Derry JM, Jain A. Impaired dendritic-cell function in ectodermal dysplasia with immune deficiency is linked to defective NEMO ubiquitination. Blood 2006 ; 108 : 2324-2331.

Louis-Marie Charbonnier, PhD, joined IMI in February 2008 as post-doctoral fellow in the group of Alain Le Moine, MD-PhD.  Louis-Marie Charbonnier recently graduated as PhD from the University of Montpellier after completion of his research studies on atypical regulatory cells in a mouse model of rheumatoid arthritis.  At IMI, Louis Marie Charbonnier will collaborate with Benoît Vokaer under the supervision of Alain-Le Moine to investigate the role interleukin 17 in allograft rejection.

Key bibliographic references of Louis-Marie Charbonnier

Charbonnier LM, van Duivenvoorde LM, Apparailly F, Cantos C, Han WG, Noël D, Duperray C, Huizinga TW, Toes RE, Jorgensen C, Louis-Plence P. Immature dendritic cells suppress Collagen-Induced Arthritis by in vivo expansion of CD49b⁺ regulatory T cells. J Immunol 2006 ; 177 : 3806-13

Djouad F, Charbonnier LM, Bouffi C, Louis-Plence P, Bony C, Apparailly F, Cantos C, Jorgensen C, Noël D. Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleikin-6-dependent mechanism. Stem Cells 2007 ; 35 : 2025-2032.