, MD-PhD student in the group of Arnaud Marchant, recently completed a study dissecting the responses of T lymphocytes elicited by the hepatitis B vaccine in humans. This work, which is part of a collaborative project with Oberdan Leo, Fabienne Andris and Fouad Eddahri (Immunology Laboratory, IBMM
), was just published in the Journal of Immunology
, the journal of the American Association of Immunologists
(J Immunol 2006 : 177 ; 8185-8190). The reported findings reveal the complexity of memory T cell subsets and supports the concept that T lymphocytes expressing CCR7 - a chemokine receptor involved in the homing of lymphocytes in lymph nodes - are capable of self-renewal and thereby contribute to maintain the pool of memory cells after vaccination. These observations are important for the development of new biomarkers to assess the efficacy of vaccines.