Transcription factors of the NF-kB family play critical roles in several inflammatory disorders. Inhibiting NF-kB activation family has been proposed as a strategy to promote immune tolerance in organ transplantation. Fabrice Moore, a PhD student working at the IMI under the supervision of Véronique Flamand, generated in collaboration with the laboratory of Kris Thielemans (Laboratory of Molecular and Cellular Therapy, Vrije Universiteit of Brussels) murine dendritic cells expressing a mutated IkBa acting as a superrepressor of the classical pathway of NF-kB signalling. Using these tools, he demonstrated that a non-classical pathway of NF-kB activation might represent an alternate mechanism for transplant rejection. This work is published in the February 2007 issue of the Journal of Immunology, the official journal of the American Association of Immunologists.

Related reference: Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M, Flamand V. An alternative pathway of NF-kB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkBalpha. J Immunol 2007, 178:1301-1311. View Abstract